MTV Studios is studio house owned by MTV. Astor Plaza houses the MTV Studios, owned by Viacom, the building's primary tenant. The studios are located on the mezzanine second story of the building. MTV acquired it in 1997. The Midtown Studio is used by various MTV programming, MTV News, VH1's Big Morning Buzz Live and on occasion Nickelodeon and Comedy Central. The MTV Studios also include dressing rooms, control rooms, a cafeteria, and some offices.
Little Mix gave a performance at the studios on December 16, 2016.